Fa'amatalaga Lautele
Alpha-fetoprotein (AFP) o loʻo faʻavasegaina o se sui o le albuminoid gene superfamily e aofia ai le albumin, AFP, vitamini D (Gc) protein, ma le alpha-albumin.O le AFP o se glycoprotein o 591 amino acids ma se vaega o le carbohydrate.O le AFP o se tasi lea o polotini fa'apitoa e fa'aafuafua ma o se porotini sili ona malosi i le toto i le amataga o le olaga fa'aafuafua o le tagata i le masina e tasi, pe a iai le albumin ma le transferrin i ni vaega laiti.E muamua fa'apipi'iina i totonu o le tagata e le taga samasama ma le ate (1-2 masina) ma mulimuli ane fa'ateleina i le ate.O se vaega itiiti o le AFP e gaosia e le GI tract o le manatu o le tagata.Ua faʻamaonia e mafai e le AFP ona toe faʻaalia i le serum i le maualuga o le aofaʻi i le olaga matua faʻatasi ma faiga faʻaleleia masani ma le tuputupu aʻe leaga.Alpha-fetoprotein (AFP) o se faʻailoga faʻapitoa mo le kanesa o le hepatocellular (HCC), teratoblastomas, ma neural tube defect (NTD).
Fautuaga paga | CLIA (Pu'e-Su'eina): 3C8-6 ~ 11D1-2 8A3-7 ~ 11D1-2 |
mama | >95%, fuafuaina e le SDS-PAGE |
Fausia Fa'amau | PBS, pH7.4. |
Teuina | Teu i lalo o tulaga sterile i le -20℃i le -80℃ina ua maua. Fautuaina e fa'amama le polotini i ni vaega laiti mo le teuina lelei. |
Igoa Oloa | Pusi.Leai | Clone ID |
AFP | AB0069-1 | 11D1-2 |
AB0069-2 | 3C8-6 | |
AB0069-3 | 8A3-7 |
Fa'aaliga: Bioantibody e mafai ona fa'avasega le aofa'i mo lou mana'oga.
1.Mizejewski GJ.(2001) Alpha-fetoprotein Structure and Function: Fa'atatau i Isoforms, Epitopes, ma Conformational Variants.Exp Biol Med.226(5): 377-408.
2.Tomasi TB, et al.(1977) Faʻatulagaina ma Galuega ole Alpha-Fetoprotein.Iloiloga Fa'aletausaga o Fa'afoma'i.28:453-65.
3. Leguy MC, et al.(2011) Iloiloga o le AFP i le vai amniotic: faʻatusatusaga o auala faʻaautomatika e tolu.Ann Biol Clin.69(4): 441-6.