Fa'amatalaga Lautele
Pepsinogen I, o mea muamua o le pepsin, e gaosia e le gastric mucosa ma tuʻuina atu i totonu ole gastric lumen ma peripheral circulation.Pepsinogen e aofia ai se filifili polypeptide tasi o 375 amino acids ma le mamafa molecular averesi o 42 kD.PG I (isoenzyme 1-5) e fa'alilolilo tele e sela sili i le mucosa fundic, ae o le PG II (isoenzyme 6-7) e fa'alilolilo e le pyloric glands ma le proximal duodenal mucosa.
O le Precursor e atagia ai le aofa'i o sela i luga o le manava fa'apea fo'i sela glandular, ma mata'ituina le atrophy o le manava.Latou te matua'i mautu fo'i ona latou te faia a latou galuega i lalo o tulaga faigata o lo'o i ai i totonu o le faiga o mea'ai.O le atrophy o le corpus mucosa e oʻo atu ai i le maualalo o le tuʻufaʻatasia o pepsinogen I ma o le mea lea e maualalo ai le tuʻuina atu i totonu o le toto.Serum pepsinogen I o loʻo faʻaalia ai le gaioiga ma tulaga o le mucosa gastric.
Fautuaga paga | CLIA (Pu'e-Su'eina): 1C1-3 ~ 1G7-3 1E3-1 ~ 1G7-3 |
mama | >95%, fuafuaina e le SDS-PAGE |
Fausia Fa'amau | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4 |
Teuina | Teuina i lalo o tulaga faʻamaʻi ile -20 ℃ i le -80 ℃ pe a maua. Fautuaina e fa'amama le polotini i ni vaega laiti mo le teuina lelei. |
Igoa Oloa | Pusi.Leai | Clone ID |
PGI | AB0005-1 | 1C1-3 |
AB0005-2 | 1E3-1 | |
AB0005-3 | 1G7-3 |
Fa'aaliga: Bioantibody e mafai ona fa'avasega le aofa'i mo lou mana'oga.
1.Sipponen P , Ranta P , Helske T , et al.Le maualuga ole sua ole gastrin-17 ma pepsinogen I ile gastritis atrophic: o se su'esu'ega fa'ata'ita'iga.[J].Scandinavian Journal of Gastroenterology, 2002, 37 (7): 785-791.
2.Mangla JC , Schenk EA , Desbaillets L , et al.Pepsin secretion, pepsinogen, and gastrin in Barrett's esophagus'.Uiga fa'apitoa fa'apitoa ma morphological [J].Gastroenterology, 1976, 70 (5 PT.1): 669-676.